In vitro antiviral activity of Griffithsin against porcine epidemic diarrhea virus
Identifieur interne : 000D40 ( Main/Exploration ); précédent : 000D39; suivant : 000D41In vitro antiviral activity of Griffithsin against porcine epidemic diarrhea virus
Auteurs : Lan Li ; Xiaoming Yu ; Haoming Zhang ; Haiwei Cheng ; Liting Hou ; Qisheng Zheng ; Jibo HouSource :
- Virus Genes [ 0920-8569 ] ; 2019.
Abstract
Griffithsin is a lectin with potent antiviral activity against enveloped viruses. The objective of this study was to assess Griffithsin’s inhibitory effect on porcine epidemic diarrhea virus (PEDV). The results showed that Griffithsin reduced PEDV infection of Vero cells by approximately 82.8%. Moreover, using time-of-addition assays and RT-qPCR, we found that delayed addition of Griffithsin had a weaker inhibitory effect on PEDV than earlier treatment. The mechanism of Griffithsin’s action against PEDV involved both preventing viral attachment to host cells and disrupting cell-to-cell transmission; its dual mode of action distinguished Griffithsin from most other antiviral drugs. In conclusion, Griffithsin was identified as a potent PEDV inhibitor and may represent a candidate drug for preventing PEDV infection.
Url:
DOI: 10.1007/s11262-019-01633-7
PubMed: 30637608
PubMed Central: 7089098
Affiliations:
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China</wicri:noCountry></affiliation></author><author><name sortKey="Yu, Xiaoming" sort="Yu, Xiaoming" uniqKey="Yu X" first="Xiaoming" last="Yu">Xiaoming Yu</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0017 5204</institution-id><institution-id institution-id-type="GRID">grid.454840.9</institution-id><institution>National Research Center of Engineering and Technology for Veterinary Biologicals,</institution><institution>Jiangsu Academy of Agricultural Sciences,</institution></institution-wrap>Nanjing, 210014 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210014 Jiangsu China</wicri:noCountry></affiliation></author><author><name sortKey="Zhang, Haoming" sort="Zhang, Haoming" uniqKey="Zhang H" first="Haoming" last="Zhang">Haoming Zhang</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0017 5204</institution-id><institution-id 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China</wicri:noCountry></affiliation></author><author><name sortKey="Hou, Liting" sort="Hou, Liting" uniqKey="Hou L" first="Liting" last="Hou">Liting Hou</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0017 5204</institution-id><institution-id institution-id-type="GRID">grid.454840.9</institution-id><institution>National Research Center of Engineering and Technology for Veterinary Biologicals,</institution><institution>Jiangsu Academy of Agricultural Sciences,</institution></institution-wrap>Nanjing, 210014 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210014 Jiangsu China</wicri:noCountry></affiliation></author><author><name sortKey="Zheng, Qisheng" sort="Zheng, Qisheng" uniqKey="Zheng Q" first="Qisheng" last="Zheng">Qisheng Zheng</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0017 5204</institution-id><institution-id institution-id-type="GRID">grid.454840.9</institution-id><institution>National Research Center of Engineering and Technology for Veterinary Biologicals,</institution><institution>Jiangsu Academy of Agricultural Sciences,</institution></institution-wrap>Nanjing, 210014 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210014 Jiangsu China</wicri:noCountry></affiliation></author><author><name sortKey="Hou, Jibo" sort="Hou, Jibo" uniqKey="Hou J" first="Jibo" last="Hou">Jibo Hou</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0017 5204</institution-id><institution-id institution-id-type="GRID">grid.454840.9</institution-id><institution>National Research Center of Engineering and Technology for Veterinary Biologicals,</institution><institution>Jiangsu Academy of Agricultural Sciences,</institution></institution-wrap>Nanjing, 210014 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210014 Jiangsu China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff2">Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, 225009 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">225009 Jiangsu China</wicri:noCountry></affiliation></author></analytic><series><title level="j">Virus Genes</title><idno type="ISSN">0920-8569</idno><idno type="eISSN">1572-994X</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">Griffithsin is a lectin with potent antiviral activity against enveloped viruses. The objective of this study was to assess Griffithsin’s inhibitory effect on porcine epidemic diarrhea virus (PEDV). The results showed that Griffithsin reduced PEDV infection of Vero cells by approximately 82.8%. Moreover, using time-of-addition assays and RT-qPCR, we found that delayed addition of Griffithsin had a weaker inhibitory effect on PEDV than earlier treatment. The mechanism of Griffithsin’s action against PEDV involved both preventing viral attachment to host cells and disrupting cell-to-cell transmission; its dual mode of action distinguished Griffithsin from most other antiviral drugs. In conclusion, Griffithsin was identified as a potent PEDV inhibitor and may represent a candidate drug for preventing PEDV infection.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Mori, T" uniqKey="Mori T">T Mori</name></author><author><name sortKey="O Eefe, Br" uniqKey="O Eefe B">BR O’Keefe</name></author><author><name sortKey="Sowder, Rc" uniqKey="Sowder R">RC Sowder</name></author><author><name sortKey="Bringans, S" uniqKey="Bringans S">S Bringans</name></author><author><name sortKey="Gardella, R" uniqKey="Gardella R">R Gardella</name></author><author><name sortKey="Berg, S" uniqKey="Berg S">S Berg</name></author><author><name sortKey="Cochran, P" uniqKey="Cochran P">P Cochran</name></author><author><name sortKey="Turpin, Ja" uniqKey="Turpin J">JA Turpin</name></author><author><name sortKey="Buckheit, Rw" uniqKey="Buckheit R">RW Buckheit</name></author><author><name sortKey="Mcmahon, Jb" uniqKey="Mcmahon J">JB McMahon</name></author><author><name sortKey="Boyd, Mr" uniqKey="Boyd M">MR Boyd</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lusvarghi, S" uniqKey="Lusvarghi S">S Lusvarghi</name></author><author><name sortKey="Bewley, Ca" uniqKey="Bewley C">CA Bewley</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Ziolkowska, N" uniqKey="Ziolkowska N">N Ziolkowska</name></author><author><name sortKey="O Eefe, Br" uniqKey="O Eefe B">BR O’Keefe</name></author><author><name sortKey="Mori, T" uniqKey="Mori T">T Mori</name></author><author><name sortKey="Zhu, C" uniqKey="Zhu C">C Zhu</name></author><author><name sortKey="Giomarelli, B" uniqKey="Giomarelli B">B Giomarelli</name></author><author><name sortKey="Vojdani, F" uniqKey="Vojdani F">F Vojdani</name></author><author><name sortKey="Palmer, K" uniqKey="Palmer K">K Palmer</name></author><author><name sortKey="Mcmahon, Jb" uniqKey="Mcmahon J">JB McMahon</name></author><author><name sortKey="Wlodawer, A" uniqKey="Wlodawer A">A Wlodawer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Millet, Jk" uniqKey="Millet J">JK Millet</name></author><author><name sortKey="Seron, K" uniqKey="Seron K">K Séron</name></author><author><name sortKey="Labitt, Rn" uniqKey="Labitt R">RN Labitt</name></author><author><name sortKey="Danneels, A" uniqKey="Danneels A">A Danneels</name></author><author><name sortKey="Palmer, Ke" uniqKey="Palmer K">KE Palmer</name></author><author><name sortKey="Whittaker, Gr" uniqKey="Whittaker G">GR Whittaker</name></author><author><name sortKey="Dubuisson, J" uniqKey="Dubuisson J">J Dubuisson</name></author><author><name sortKey="Belouzard, S" uniqKey="Belouzard S">S Belouzard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Takebe, Y" uniqKey="Takebe Y">Y Takebe</name></author><author><name sortKey="Saucedo, Cj" uniqKey="Saucedo C">CJ Saucedo</name></author><author><name sortKey="Lund, G" uniqKey="Lund G">G Lund</name></author><author><name sortKey="Uenishi, R" uniqKey="Uenishi R">R Uenishi</name></author><author><name sortKey="Hase, S" uniqKey="Hase S">S Hase</name></author><author><name sortKey="Tsuchiura, T" uniqKey="Tsuchiura T">T Tsuchiura</name></author><author><name sortKey="Kneteman, N" uniqKey="Kneteman N">N Kneteman</name></author><author><name sortKey="Ramessar, K" uniqKey="Ramessar K">K Ramessar</name></author><author><name sortKey="Tyrrell, Dl" uniqKey="Tyrrell D">DL Tyrrell</name></author><author><name sortKey="Shirakura, M" uniqKey="Shirakura M">M Shirakura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nixon, B" uniqKey="Nixon B">B Nixon</name></author><author><name sortKey="Stefanidou, M" uniqKey="Stefanidou M">M Stefanidou</name></author><author><name sortKey="Mesquita, Pm" uniqKey="Mesquita P">PM Mesquita</name></author><author><name sortKey="Fakioglu, E" uniqKey="Fakioglu E">E Fakioglu</name></author><author><name sortKey="Segarra, T" uniqKey="Segarra T">T Segarra</name></author><author><name sortKey="Rohan, L" uniqKey="Rohan L">L Rohan</name></author><author><name sortKey="Halford, W" uniqKey="Halford W">W Halford</name></author><author><name sortKey="Palmer, Ke" uniqKey="Palmer K">KE Palmer</name></author><author><name sortKey="Herold, Bc" uniqKey="Herold B">BC Herold</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ishag, Hz" uniqKey="Ishag H">HZ Ishag</name></author><author><name sortKey="Li, C" uniqKey="Li C">C Li</name></author><author><name sortKey="Wang, F" uniqKey="Wang F">F Wang</name></author><author><name sortKey="Mao, X" uniqKey="Mao X">X Mao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ishag, Hza" uniqKey="Ishag H">HZA Ishag</name></author><author><name sortKey="Li, C" uniqKey="Li C">C Li</name></author><author><name sortKey="Huang, L" uniqKey="Huang L">L Huang</name></author><author><name sortKey="Sun, Mx" uniqKey="Sun M">MX Sun</name></author><author><name sortKey="Wang, F" uniqKey="Wang F">F Wang</name></author><author><name sortKey="Ni, B" uniqKey="Ni B">B Ni</name></author><author><name sortKey="Malik, T" uniqKey="Malik T">T Malik</name></author><author><name sortKey="Chen, Py" uniqKey="Chen P">PY Chen</name></author><author><name sortKey="Mao, X" uniqKey="Mao X">X Mao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Levendosky, K" uniqKey="Levendosky K">K Levendosky</name></author><author><name sortKey="Mizenina, O" uniqKey="Mizenina O">O Mizenina</name></author><author><name sortKey="Martinelli, E" uniqKey="Martinelli E">E Martinelli</name></author><author><name sortKey="Jeanpierre, N" uniqKey="Jeanpierre N">N Jeanpierre</name></author><author><name sortKey="Kizima, L" uniqKey="Kizima L">L Kizima</name></author><author><name sortKey="Rodriguez, A" uniqKey="Rodriguez A">A Rodriguez</name></author><author><name sortKey="Kleinbeck, K" uniqKey="Kleinbeck K">K Kleinbeck</name></author><author><name sortKey="Bonnaire, T" uniqKey="Bonnaire T">T Bonnaire</name></author><author><name sortKey="Robbiani, M" uniqKey="Robbiani M">M Robbiani</name></author><author><name sortKey="Zydowsky, Tm" uniqKey="Zydowsky T">TM Zydowsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kouokam, Jc" uniqKey="Kouokam J">JC Kouokam</name></author><author><name sortKey="Huskens, D" uniqKey="Huskens D">D Huskens</name></author><author><name sortKey="Schols, D" uniqKey="Schols D">D Schols</name></author><author><name sortKey="Johannemann, A" uniqKey="Johannemann A">A Johannemann</name></author><author><name sortKey="Riedell, Sk" uniqKey="Riedell S">SK Riedell</name></author><author><name sortKey="Walter, W" uniqKey="Walter W">W Walter</name></author><author><name sortKey="Walker, Jm" uniqKey="Walker J">JM Walker</name></author><author><name sortKey="Matoba, N" uniqKey="Matoba N">N Matoba</name></author><author><name sortKey="O Eefe, Br" uniqKey="O Eefe B">BR O’Keefe</name></author><author><name sortKey="Palmer, Ke" uniqKey="Palmer K">KE Palmer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fuqua, Jl" uniqKey="Fuqua J">JL Fuqua</name></author><author><name sortKey="Wanga, V" uniqKey="Wanga V">V Wanga</name></author><author><name sortKey="Palmer, Ke" uniqKey="Palmer K">KE Palmer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moncla, Bj" uniqKey="Moncla B">BJ Moncla</name></author><author><name sortKey="Pryke, K" uniqKey="Pryke K">K Pryke</name></author><author><name sortKey="Rohan, Lc" uniqKey="Rohan L">LC Rohan</name></author><author><name sortKey="Graebing, Pw" uniqKey="Graebing P">PW Graebing</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Diel, Dg" uniqKey="Diel D">DG Diel</name></author><author><name sortKey="Lawson, S" uniqKey="Lawson S">S Lawson</name></author><author><name sortKey="Okda, F" uniqKey="Okda F">F Okda</name></author><author><name sortKey="Singrey, A" uniqKey="Singrey A">A Singrey</name></author><author><name sortKey="Clement, T" uniqKey="Clement T">T Clement</name></author><author><name sortKey="Fernandes, Mh" uniqKey="Fernandes M">MH Fernandes</name></author><author><name sortKey="Christopher Hennings, J" uniqKey="Christopher Hennings J">J Christopher-Hennings</name></author><author><name sortKey="Nelson, Ea" uniqKey="Nelson E">EA Nelson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, D" uniqKey="Wang D">D Wang</name></author><author><name sortKey="Fang, L" uniqKey="Fang L">L Fang</name></author><author><name sortKey="Xiao, S" uniqKey="Xiao S">S Xiao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Hj" uniqKey="Li H">HJ Li</name></author><author><name sortKey="Gao, Ds" uniqKey="Gao D">DS Gao</name></author><author><name sortKey="Li, Yt" uniqKey="Li Y">YT Li</name></author><author><name sortKey="Wang, Ys" uniqKey="Wang Y">YS Wang</name></author><author><name sortKey="Liu, Hy" uniqKey="Liu H">HY Liu</name></author><author><name sortKey="Zhao, J" uniqKey="Zhao J">J Zhao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, C" uniqKey="Lee C">C Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hwajung, C" uniqKey="Hwajung C">C Hwajung</name></author><author><name sortKey="Jinhee, K" uniqKey="Jinhee K">K Jinhee</name></author><author><name sortKey="Choonghwan, L" uniqKey="Choonghwan L">L Choonghwan</name></author><author><name sortKey="Youngjoon, A" uniqKey="Youngjoon A">A Youngjoon</name></author><author><name sortKey="Song, Jh" uniqKey="Song J">JH Song</name></author><author><name sortKey="Seunghwa, B" uniqKey="Seunghwa B">B Seunghwa</name></author><author><name sortKey="Durhan, K" uniqKey="Durhan K">K Durhan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Q" uniqKey="Yang Q">Q Yang</name></author><author><name sortKey="Gao, L" uniqKey="Gao L">L Gao</name></author><author><name sortKey="Si, J" uniqKey="Si J">J Si</name></author><author><name sortKey="Sun, Y" uniqKey="Sun Y">Y Sun</name></author><author><name sortKey="Liu, J" uniqKey="Liu J">J Liu</name></author><author><name sortKey="Cao, L" uniqKey="Cao L">L Cao</name></author><author><name sortKey="Feng, Wh" uniqKey="Feng W">WH Feng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Keirstead, Nd" uniqKey="Keirstead N">ND Keirstead</name></author><author><name sortKey="Lee, C" uniqKey="Lee C">C Lee</name></author><author><name sortKey="Yoo, D" uniqKey="Yoo D">D Yoo</name></author><author><name sortKey="Brooks, As" uniqKey="Brooks A">AS Brooks</name></author><author><name sortKey="Hayes, Ma" uniqKey="Hayes M">MA Hayes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhu, P" uniqKey="Zhu P">P Zhu</name></author><author><name sortKey="Liu, J" uniqKey="Liu J">J Liu</name></author><author><name sortKey="Bess, J" uniqKey="Bess J">J Bess</name></author><author><name sortKey="Chertova, E" uniqKey="Chertova E">E Chertova</name></author><author><name sortKey="Lifson, Jd" uniqKey="Lifson J">JD Lifson</name></author><author><name sortKey="Grise, H" uniqKey="Grise H">H Grisé</name></author><author><name sortKey="Ofek, Ga" uniqKey="Ofek G">GA Ofek</name></author><author><name sortKey="Taylor, Ka" uniqKey="Taylor K">KA Taylor</name></author><author><name sortKey="Roux, Kh" uniqKey="Roux K">KH Roux</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="O Eefe, Br" uniqKey="O Eefe B">BR O’Keefe</name></author><author><name sortKey="Giomarelli, B" uniqKey="Giomarelli B">B Giomarelli</name></author><author><name sortKey="Barnard, Dl" uniqKey="Barnard D">DL Barnard</name></author><author><name sortKey="Shenoy, Sr" uniqKey="Shenoy S">SR Shenoy</name></author><author><name sortKey="Chan, Pks" uniqKey="Chan P">PKS Chan</name></author><author><name sortKey="Mcmahon, Jb" uniqKey="Mcmahon J">JB Mcmahon</name></author><author><name sortKey="Palmer, Ke" uniqKey="Palmer K">KE Palmer</name></author><author><name sortKey="Barnett, Bw" uniqKey="Barnett B">BW Barnett</name></author><author><name sortKey="Meyerholz, Dk" uniqKey="Meyerholz D">DK Meyerholz</name></author><author><name sortKey="Wohlfordlenane, Cl" uniqKey="Wohlfordlenane C">CL Wohlfordlenane</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meuleman, P" uniqKey="Meuleman P">P Meuleman</name></author><author><name sortKey="Albecka, A" uniqKey="Albecka A">A Albecka</name></author><author><name sortKey="Belouzard, S" uniqKey="Belouzard S">S Belouzard</name></author><author><name sortKey="Vercauteren, K" uniqKey="Vercauteren K">K Vercauteren</name></author><author><name sortKey="Verhoye, L" uniqKey="Verhoye L">L Verhoye</name></author><author><name sortKey="Wychowski, C" uniqKey="Wychowski C">C Wychowski</name></author><author><name sortKey="Lerouxroels, G" uniqKey="Lerouxroels G">G Lerouxroels</name></author><author><name sortKey="Palmer, Ke" uniqKey="Palmer K">KE Palmer</name></author><author><name sortKey="Dubuisson, J" uniqKey="Dubuisson J">J Dubuisson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barton, C" uniqKey="Barton C">C Barton</name></author><author><name sortKey="Kouokam, J" uniqKey="Kouokam J">J Kouokam</name></author><author><name sortKey="Hurst, H" uniqKey="Hurst H">H Hurst</name></author><author><name sortKey="Palmer, K" uniqKey="Palmer K">K Palmer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barton, C" uniqKey="Barton C">C Barton</name></author><author><name sortKey="Kouokam, Jc" uniqKey="Kouokam J">JC Kouokam</name></author><author><name sortKey="Lasnik, Ab" uniqKey="Lasnik A">AB Lasnik</name></author><author><name sortKey="Foreman, O" uniqKey="Foreman O">O Foreman</name></author><author><name sortKey="Cambon, A" uniqKey="Cambon A">A Cambon</name></author><author><name sortKey="Brock, G" uniqKey="Brock G">G Brock</name></author><author><name sortKey="Montefiori, Dc" uniqKey="Montefiori D">DC Montefiori</name></author><author><name sortKey="Vojdani, F" uniqKey="Vojdani F">F Vojdani</name></author><author><name sortKey="Mccormick, Aa" uniqKey="Mccormick A">AA Mccormick</name></author><author><name sortKey="O Eefe, Br" uniqKey="O Eefe B">BR O’Keefe</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Cheng, Haiwei" sort="Cheng, Haiwei" uniqKey="Cheng H" first="Haiwei" last="Cheng">Haiwei Cheng</name><name sortKey="Hou, Jibo" sort="Hou, Jibo" uniqKey="Hou J" first="Jibo" last="Hou">Jibo Hou</name><name sortKey="Hou, Liting" sort="Hou, Liting" uniqKey="Hou L" first="Liting" last="Hou">Liting Hou</name><name sortKey="Li, Lan" sort="Li, Lan" uniqKey="Li L" first="Lan" last="Li">Lan Li</name><name sortKey="Yu, Xiaoming" sort="Yu, Xiaoming" uniqKey="Yu X" first="Xiaoming" last="Yu">Xiaoming Yu</name><name sortKey="Zhang, Haoming" sort="Zhang, Haoming" uniqKey="Zhang H" first="Haoming" last="Zhang">Haoming Zhang</name><name sortKey="Zheng, Qisheng" sort="Zheng, Qisheng" uniqKey="Zheng Q" first="Qisheng" last="Zheng">Qisheng Zheng</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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